someone holding a magnifying glass over their skin to show red bumps

The U.S. Food and Drug Administration has published a warning that the anti-seizure medication Onfi (clobazam) may cause severe skin problems leading to permanent injury or even death. While the skin reactions are rare, the potential for serious harm is a real health threat.

Accordingly, the FDA has approved revisions to the Onfi drug label and patient Medication Guide so that physicians and users alike are aware of the risks of harm from the drug.

Patients who take Onfi should not delay in receiving medical treatment if they see any signs of a rash, blistering or peeling of the skin, sores in the mouth or hives. Medical professionals are urged to discontinue use of Onfi and find other treatments if they notice any rashes on their patients. The only exception is if the skin reaction is obviously not drug-related.

Stevens-Johnson syndrome and toxic epidermal necrolysis are uncommon but dangerous skin conditions that can appear at any time when Onfi is prescribed. Reactions are most likely to occur in the first eight weeks of treatment or when Onfi is stopped and then restarted again. Patients who developed Stevens-Johnson syndrome or toxic epidermal necrolysis had to be hospitalized. One case resulted in blindness and another ended in death.

Speak With Your Doctor

Onfi is a benzodiazepine medication that is intended to be used in combination with other medicines to treat seizures caused by a serious kind of epilepsy called Lennox-Gastaut syndrome. In general, severe skin conditions have not been linked with other benzodiazepine medicines.

Patients are advised not to stop taking Onfi before speaking with their doctors. By abruptly discontinuing this medication, serious withdrawal issues may follow such as constant seizures, hallucinations, shaking, anxiety and stomach or muscle cramps.

It’s possible that Onfi could cause serious reactions even if you don’t have a history of skin problems. That’s why you should seek immediate medical attention.

About the Author

Since 1968, the South Carolina personal injury and workers’ compensation attorneys of Joye Law Firm have been committed to securing compensation for accident and injury victims. Our compassionate and dedicated lawyers have over 300 years of combined litigation experience, and many of them have been recognized as South Carolina Super Lawyers. For many years, our South Carolina personal injury law firm has been listed with an AV rating in the prestigious Martindale-Hubbell legal directory.

Recent Blog Post
One man being stopped from grabbing keys after drinking
South Carolina’s Tort Reform Debate: Who Really Benefits From S.244?

The South Carolina legislature is once again embroiled in a heated debate over tort reform, particularly with the introduction of Bill S.244. Proponents claim this bill will create a more favorable business climate by limiting liability, but the reality is…

Emergency Department Sign
Does Workers’ Compensation Cover Emergency Room Visits?

If you were hurt at work and ended up in the emergency room, you’re likely wondering if workers’ compensation will pay for that visit. The good news is, in South Carolina, workers’ compensation generally does cover emergency room visits for…

work comp denials
What Is the Exclusive Remedy Doctrine?

If you’re in the process of filing a workers’ compensation claim, you may have come across the term “exclusive remedy doctrine” and wondered, “What is the exclusive remedy doctrine, and how does it affect my case?” This principle is central…

Attorney taking notes
What Happens When You Reject an Insurance Settlement Offer?

Getting hurt because of someone else’s negligence can throw your life off track. Beyond the physical pain, you’re often left with mounting medical bills, lost wages, and uncertainty about what the future holds. When dealing with an insurance claim, it’s…

Awards & Recognition
Media
ABC
NBC
Fox
CBS News
ESPN Radio logo